Acetyl-Histone H4-K12 Polyclonal Antibody

Background:
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
HIST1H4B, H4/I, H4FI, histone H4, Histone H4, HIST1H4A, HIST2H4A, FO108, H4, H4/n, H4F2, H4FN, HIST2H4

Immunogen: A synthetic acetylated peptide around K12 of human Histone H4 (NP_001029249.1).

Swissprot: P62805
Gene ID: 8366

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.