ACK1 Antibody (Center Y284) Blocking peptide
€363.00
In stock
SKU
AC-BP13936c
Background:
This gene encodes a tyrosine kinase that binds Cdc42Hs inits GTP-bound form and inhibits both the intrinsic andGTPase-activating protein (GAP)-stimulated GTPase activity ofCdc42Hs. This binding is mediated by a unique sequence of 47 aminoacids C-terminal to an SH3 domain. The protein may be involved in aregulatory mechanism that sustains the GTP-bound active form ofCdc42Hs and which is directly linked to a tyrosine phosphorylationsignal transduction pathway. Several alternatively splicedtranscript variants have been identified from this gene, but thefull-length nature of only two transcript variants has beendetermined.
Other Names:
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13936c was selected from the Center Y284 region of ACK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TNK2
Gene ID: 10188
Primary Accession: Q07912
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a tyrosine kinase that binds Cdc42Hs inits GTP-bound form and inhibits both the intrinsic andGTPase-activating protein (GAP)-stimulated GTPase activity ofCdc42Hs. This binding is mediated by a unique sequence of 47 aminoacids C-terminal to an SH3 domain. The protein may be involved in aregulatory mechanism that sustains the GTP-bound active form ofCdc42Hs and which is directly linked to a tyrosine phosphorylationsignal transduction pathway. Several alternatively splicedtranscript variants have been identified from this gene, but thefull-length nature of only two transcript variants has beendetermined.
Other Names:
Activated CDC42 kinase 1, ACK-1, Tyrosine kinase non-receptor protein 2, TNK2, ACK1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13936c was selected from the Center Y284 region of ACK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TNK2
Gene ID: 10188
Primary Accession: Q07912
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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