ACTH [clone AH26], anti-human, mouse, rat
€0.00
In stock
SKU
MC0279
Catalog Number: MC0279Clone: AH26Isotype: Mouse IgG1kApplications: Flow Cyt.(0.5-1ug/million cells), ICC/IF (1-2ug/ml), IHC
Request Manual
Questions? Contact us!
Request Manual
Questions? Contact us!
Description: ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs).ĀIt also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.Localization: cytoplasmDilution: 50-200Positive Control: pituitary gland or pituitary adenomaHIER: citrate pH6.0 or EDTA pH8.0Status: RUO
Is Featured? | No |
---|
Write Your Own Review