ACY1 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP12050c
Background:
This gene encodes a cytosolic, homodimeric, zinc-bindingenzyme that catalyzes the hydrolysis of acylated L-amino acids toL-amino acids and an acyl group, and has been postulated tofunction in the catabolism and salvage of acylated amino acids.This gene is located on chromosome 3p21.1, a region reduced tohomozygosity in small-cell lung cancer (SCLC), and its expressionhas been reported to be reduced or undetectable in SCLC cell linesand tumors. The amino acid sequence of human aminoacylase-1 ishighly homologous to the porcine counterpart, and this enzyme isthe first member of a new family of zinc-binding enzymes. Mutationsin this gene cause aminoacylase-1 deficiency, a metabolic disordercharacterized by central nervous system defects and increasedurinary excretion of N-acetylated amino acids. Alternative splicingof this gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the upstreamABHD14A (abhydrolase domain containing 14A) gene, as represented inGeneID:100526760. A related pseudogene has been identified onchromosome 18.
Other Names:
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1
Gene Name: ACY1
Gene ID: 95
Primary Accession: Q03154
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a cytosolic, homodimeric, zinc-bindingenzyme that catalyzes the hydrolysis of acylated L-amino acids toL-amino acids and an acyl group, and has been postulated tofunction in the catabolism and salvage of acylated amino acids.This gene is located on chromosome 3p21.1, a region reduced tohomozygosity in small-cell lung cancer (SCLC), and its expressionhas been reported to be reduced or undetectable in SCLC cell linesand tumors. The amino acid sequence of human aminoacylase-1 ishighly homologous to the porcine counterpart, and this enzyme isthe first member of a new family of zinc-binding enzymes. Mutationsin this gene cause aminoacylase-1 deficiency, a metabolic disordercharacterized by central nervous system defects and increasedurinary excretion of N-acetylated amino acids. Alternative splicingof this gene results in multiple transcript variants. Read-throughtranscription also exists between this gene and the upstreamABHD14A (abhydrolase domain containing 14A) gene, as represented inGeneID:100526760. A related pseudogene has been identified onchromosome 18.
Other Names:
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1
Gene Name: ACY1
Gene ID: 95
Primary Accession: Q03154
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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