ACY1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8150
Background:
Aminoacylase-1, also designated N-acyl-L-amino-acid amidohydrolase or ACY-1, is a member of the largest metallopeptidase family called M20A. Aminoacylase-1 is a zinc-binding homodimeric enzyme expressed in kidney, brain, placenta and spleen. It is the most abundant of the aminoacylases. Aminoacylase-1 localizes to the cytoplasm and catalyzes the hydrolysis of N-acylated or N-acetylated amino acids. In addition, Aminoacylase-1 is a sphingosine kinase 1 (SphK1)-interacting protein and may also play a role in regulating responses of the cell to oxidative stress. The gene encoding Aminoacylase-1 is evolutionarily conserved in fish, frog, mouse, rat and human. Deficiency in the Aminoacylase-1 protein may result in defects of brain metabolism and function.
Alternative Name:
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200
Specificity: ACY1 polyclonal antibody detects endogenous levels of ACY1 protein.
Immunogen:
Recombinant full length Human ACY1.
MW: ~ 46 kDa
Swis Prot.: Q03154
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Aminoacylase-1, also designated N-acyl-L-amino-acid amidohydrolase or ACY-1, is a member of the largest metallopeptidase family called M20A. Aminoacylase-1 is a zinc-binding homodimeric enzyme expressed in kidney, brain, placenta and spleen. It is the most abundant of the aminoacylases. Aminoacylase-1 localizes to the cytoplasm and catalyzes the hydrolysis of N-acylated or N-acetylated amino acids. In addition, Aminoacylase-1 is a sphingosine kinase 1 (SphK1)-interacting protein and may also play a role in regulating responses of the cell to oxidative stress. The gene encoding Aminoacylase-1 is evolutionarily conserved in fish, frog, mouse, rat and human. Deficiency in the Aminoacylase-1 protein may result in defects of brain metabolism and function.
Alternative Name:
Aminoacylase-1, ACY-1, N-acyl-L-amino-acid amidohydrolase, ACY1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200
Specificity: ACY1 polyclonal antibody detects endogenous levels of ACY1 protein.
Immunogen:
Recombinant full length Human ACY1.
MW: ~ 46 kDa
Swis Prot.: Q03154
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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