ADAM12 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60740
Background:
ADAM (a disintegr in and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNF (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signaldomain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM12 (Meltrin-α) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane-bound form (ADAM12L), and is involved in egg-sperm fusion.
Alternative Name:
Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, Meltrin-alpha, ADAM12, MLTN, UNQ346, PRO545
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADAM12 polyclonal antibody detects endogenous levels of ADAM12 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADAM12
MW: ~ 100 kDa
Swis Prot.: O43184
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ADAM (a disintegr in and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNF (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signaldomain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM12 (Meltrin-α) is produced as 2 differentially spliced isoforms, a 718 amino acid secreted form (ADAM12S) and a 881 amino acid membrane-bound form (ADAM12L), and is involved in egg-sperm fusion.
Alternative Name:
Disintegrin and metalloproteinase domain-containing protein 12, ADAM 12, Meltrin-alpha, ADAM12, MLTN, UNQ346, PRO545
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADAM12 polyclonal antibody detects endogenous levels of ADAM12 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADAM12
MW: ~ 100 kDa
Swis Prot.: O43184
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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