ADAMTS13 Antibody (Center) Blocking Peptide
€293.00
In stock
SKU
AC-BP7438c
Background:
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Other Names: A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7438c was selected from the Center region of human ADAMTS13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q76LX8
Gene ID: 11093
Gene Name: ADAMTS13
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)Levy G.G., Nichols W.C.Nature 413:488-494(2001) Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002) Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)
ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.
Other Names: A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, von Willebrand factor-cleaving protease, vWF-CP, vWF-cleaving protease, ADAMTS13, C9orf8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7438c was selected from the Center region of human ADAMTS13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q76LX8
Gene ID: 11093
Gene Name: ADAMTS13
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Zheng X., Chung D., Takayama T.K.J. Biol. Chem. 276:41059-41063(2001)Levy G.G., Nichols W.C.Nature 413:488-494(2001) Cal S., Obaya A.J., Llamazares M., Garabaya C.Gene 283:49-62(2002) Zheng X., Nishio K., Majerus E.M.J. Biol. Chem. 278:30136-30141(2003)Anderson P.J., Kokame K., Sadler J.E.J. Biol. Chem. 281:850-857(2006)Pimanda J.E., Maekawa A., Wind T.Blood 103:627-629(2004)Plaimauer B., Fuhrmann J., Mohr G.Blood 107:118-125(2006)
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