Adducin α (phospho-T445) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4258
Background:
Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Alternative Name:
Alpha-adducin, Erythrocyte adducin subunit alpha, ADD1, ADDA, α-Adducin, Adducin1, Adducin-1, α Adducin,
Application Dilution: IHC: 1:50~1:200
Specificity: p-Adducin α (T445) polyclonal antibody detects endogenous levels of Adducin α protein only when phosphorylated at Thr445.
Immunogen:
Synthetic phosphopeptide derived from human Adducin α around the phosphorylation site of Threonine 445.
MW: ~ 81 kDa
Swis Prot.: P35611
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Adducins are a family of cytoskeleton proteins encoded by three genes (α, β, γ). Adducin is a protein associated with the inner leaflet of the plasma membrane and is one of the proteins localized at the spectrin-actin junction of the membrane skeleton. The cortical actin cytoskeletal network is lost during apoptosis and Adducins are central in the cortical actin network organization. Adducin α is a cytoskeletal protein involved with sodium-pump activity in the renal tubule and is associated with hypertension. The expression of Adducin α and Adducin γ is ubiquitous in contrast to the restricted expression of Adducin β. Adducin β is expressed at high levels in brain and hematopoietic tissues, such as bone marrow, in humans, and in spleen in mice.
Alternative Name:
Alpha-adducin, Erythrocyte adducin subunit alpha, ADD1, ADDA, α-Adducin, Adducin1, Adducin-1, α Adducin,
Application Dilution: IHC: 1:50~1:200
Specificity: p-Adducin α (T445) polyclonal antibody detects endogenous levels of Adducin α protein only when phosphorylated at Thr445.
Immunogen:
Synthetic phosphopeptide derived from human Adducin α around the phosphorylation site of Threonine 445.
MW: ~ 81 kDa
Swis Prot.: P35611
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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