Adeno-associated virus 8 (AAV8), intact particles (clone ADK8), anti-virus
€254.00
In stock
SKU
ARP-03-652160
Catalog Number: 03-652160
Size: 25 µl
Isotype: Mouse IgG2a, kappa
Size: 25 µl
Isotype: Mouse IgG2a, kappa
Background:
Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Decription:
For characterization of different stages of infection and very useful for analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in immunoblotting.
Clone: ADK8
Isotype: Mouse IgG2a, kappa
Immunogen: Adeno-associated virus type 8 (AAV-8) capsid proteins and virus particles
Reactivity: For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Predicted binding site: residues 586-LQQQNT-591 (cf. Gurda et al.). The antibody cannot be used for immunoblotting using denaturing conditions.
Specificity: Specific for AAV-8, found in monkey. No cross-reaction with other AAV types in immunofluorescence microscopy. With dot blot analysis weak cross-reactivity with type 1, 3, 7 and 10 was observed (Mietzsch et al. 2013).
Applications: Immunofluorescence microscopy, Immunohistochemistry, Immunoprecipitation, Affinity chromatography, Neutralization Assay, ELISA
Working Dilution: Ready-to-use for immunohistochemical applications
Storage: 2-8C
Adeno-associated virus (AAV) is a small virus which infects humans and some other primate species. AAV is not currently known to cause disease and consequently the virus causes a very mild immune response. Gene therapy vectors using AAV can infect both dividing and quiescent cells and persist in an extrachromosomal state without integrating into the genome of the host cell. These features make AAV a very attractive candidate for creating viral vectors for gene therapy, and for the creation of isogenic human disease models
Decription:
For characterization of different stages of infection and very useful for analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in immunoblotting.
Clone: ADK8
Isotype: Mouse IgG2a, kappa
Immunogen: Adeno-associated virus type 8 (AAV-8) capsid proteins and virus particles
Reactivity: For characterization of different stages of infection and very useful for the analysis of the AAV assembly process. ADK8 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Predicted binding site: residues 586-LQQQNT-591 (cf. Gurda et al.). The antibody cannot be used for immunoblotting using denaturing conditions.
Specificity: Specific for AAV-8, found in monkey. No cross-reaction with other AAV types in immunofluorescence microscopy. With dot blot analysis weak cross-reactivity with type 1, 3, 7 and 10 was observed (Mietzsch et al. 2013).
Applications: Immunofluorescence microscopy, Immunohistochemistry, Immunoprecipitation, Affinity chromatography, Neutralization Assay, ELISA
Working Dilution: Ready-to-use for immunohistochemical applications
Storage: 2-8C
| Is Featured? | No |
|---|
Write Your Own Review