ADH7 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5600
Background:
ADH7 (alcohol dehydrogenase 7 (class IV), µ or σ polypeptide), is a 386 amino acid protein belonging to the zinc-containing alcohol dehydrogenase family and the class-IV subfamily. Seven different human ADH isozymes exist: three belong to class-I: α, β and γ; one to class-II: π; one to class-III: χ; one to class-IV: ADH7; and one to class-V: ADH6. Encoded by a gene that maps to human chromosome 4q23, ADH7 localizes to the cytoplasm and is preferentially expressed in stomach, but, unlike other family members, is absent from liver. ADH7 is a homodimer that binds two zinc ions per subunit and contains nine exons. ADH7 participates in the synthesis of retinoic acid, a hormone important for cellular differentiation. Variations in ADH7 may be associated with alcohol dependence. ADH7 may also play a role in protection against aerodigestive tract cancer.
Alternative Name:
Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase, ADH7
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADH7 polyclonal antibody detects endogenous levels of ADH7 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADH7.
MW: ~ 40 kDa
Swis Prot.: P40394
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
ADH7 (alcohol dehydrogenase 7 (class IV), µ or σ polypeptide), is a 386 amino acid protein belonging to the zinc-containing alcohol dehydrogenase family and the class-IV subfamily. Seven different human ADH isozymes exist: three belong to class-I: α, β and γ; one to class-II: π; one to class-III: χ; one to class-IV: ADH7; and one to class-V: ADH6. Encoded by a gene that maps to human chromosome 4q23, ADH7 localizes to the cytoplasm and is preferentially expressed in stomach, but, unlike other family members, is absent from liver. ADH7 is a homodimer that binds two zinc ions per subunit and contains nine exons. ADH7 participates in the synthesis of retinoic acid, a hormone important for cellular differentiation. Variations in ADH7 may be associated with alcohol dependence. ADH7 may also play a role in protection against aerodigestive tract cancer.
Alternative Name:
Alcohol dehydrogenase class 4 mu/sigma chain, Alcohol dehydrogenase class IV mu/sigma chain, Gastric alcohol dehydrogenase, Retinol dehydrogenase, ADH7
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ADH7 polyclonal antibody detects endogenous levels of ADH7 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ADH7.
MW: ~ 40 kDa
Swis Prot.: P40394
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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