AF/LE Purified Anti-Human CD20 Antibody [clone 2H7]
€0.00
In stock
SKU
E-AB-F12120
Catalog Number: E-AB-F12120
Reactivity: Human, Clone: 2H7
Isotype: Mouse IgG2b, κ, Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
Applications: Depletion, FCM, IHC, IP
Datasheet, Questions? Contact us!
Reactivity: Human, Clone: 2H7
Isotype: Mouse IgG2b, κ, Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
Applications: Depletion, FCM, IHC, IP
Datasheet, Questions? Contact us!
Background:
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
Research Area: Cancer, Immunology, Stem cells
Synonyms:
Bp35, Leukocyte surface antigen Leu-16, MS4A1, B-lymphocyte surface antigen B1
Swissprot: P11836
Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
Research Area: Cancer, Immunology, Stem cells
Synonyms:
Bp35, Leukocyte surface antigen Leu-16, MS4A1, B-lymphocyte surface antigen B1
Swissprot: P11836
Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
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