AF/LE Purified Anti-Human CD279/PD-1 Antibody [clone J110]

AF/LE Purified Anti-Human CD279/PD-1 Antibody [clone J110]

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In stock
SKU
E-AB-F12130
Catalog Number: E-AB-F12130
Reactivity: Human, Clone: J110
Isotype: Mouse IgG1, κ, Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
Applications: FCM
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Background:
Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

Research Area: Cancer, Cell Biology, Immunology

Synonyms:
PDCD1, PD1, Protein PD-1, hPD-1
Swissprot: P20701

Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Concentration: 0.5 mg/mL

Storage:
Store at 2~8°C. Do not freeze.

Alternative for product with catalog number:
329925, 329926
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