AF/LE Purified Anti-Mouse CD115 Antibody [clone AFS98]
€0.00
In stock
SKU
E-AB-F11070
Catalog Number: E-AB-F11070
Reactivity: Mouse, Clone: AFS98
Isotype: Rat IgG2a, κ, Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
Applications: Block, Depletion, Neut, FCM, WB
Datasheet, Questions? Contact us!
Reactivity: Mouse, Clone: AFS98
Isotype: Rat IgG2a, κ, Conjugation: None (Purified antibody-Azide Free/Low endotoxin)
Applications: Block, Depletion, Neut, FCM, WB
Datasheet, Questions? Contact us!
Background:
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Research Area: Cardiovascular,Immunology,Signal Transduction
Synonyms:
Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, CD115, Csf1r, Csfmr, Fms
Swissprot: P09581
Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
Alternative for product with catalog number:
135537, 135538
CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
Research Area: Cardiovascular,Immunology,Signal Transduction
Synonyms:
Macrophage colony-stimulating factor 1 receptor, CSF-1 receptor (EC:2.7.10.1), CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, CD115, Csf1r, Csfmr, Fms
Swissprot: P09581
Buffer: 0.2 μm filtered in PBS, pH7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage:
Store at 2~8°C. Do not freeze.
Alternative for product with catalog number:
135537, 135538
Is Featured? | No |
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