Aggrecan polyclonal, anti-human, mouse, rat, pig, bovine, rabbit, chicken

Protein Family: CAM Ligands, Proteoglycans

Pathway and Disease: Development and Behavior, Signaling Molecules and Interaction

Description:
Aggrecan core protein (Cartilage-specific proteoglycan core protein) is a major component of extracellular matrix of cartilagenous tissues. The major function of aggrecan is to resist compression in cartilage. Aggrecan binds avidly to hyaluronic acid via an N-terminal globular region. Expression of aggrecan is restricited to cartilages in chondrocytes throughout the developing skeleton. Aggrecan contains mostly chondroitin sulfate and lesser keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. Defects in aggrecan are the cause of spondyloepiphyseal dysplasia type Kimberley (SEDK) and spondyloepimetaphyseal dysplasia aggrecan type (SEMD-ACAN).

Alternate Names: Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, ACAN, AGC1, CSPG1, MSK16

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P16112

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human aggrecan.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Zhu Y. et al. 2015. Department of Orthopaedics. 12(4):5573-9. PMID: 26165845.
[2] Chen J et al. 2015. J Orthop Res. 33(1): 47-55. PMID# 25263345.