AK2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6319
Background:
Adenylate kinases 1-5 (designated AK1-5) are a set of enzymes that regulate the phosphorylation state of intracellular adenine nucleotides, which are the principle high-energy phosphoryl-carrying molecules in living cells. AKs influence metabolic signals, which include gene expression, ion channel activity and protein kinase-mediated signaling, by catalyzing phosphoryl transfer between adenine nucleotides (AMP, ADP, ATP). Inherited mutations leading to AK deficiencies in erythrocytes have been implicated in hemolytic anemia. AK2 is found in the mitochondria of liver and heart tissues and is the only AK that localizes to the mitochondrial intermembrane space. In apoptotic cells, AK2 is the only AK that translocates into the cytosol concomitantly with cytochrome c, suggesting that only intermembrane proteins are released from mitochondria during the early stages of apoptosis.
Alternative Name:
Adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, AK2, ADK2
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: AK2 polyclonal antibody detects endogenous levels of AK2 protein.
Immunogen:
Recombinant full length Human AK2.
MW: ~ 26 kDa
Swis Prot.: P54819
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Adenylate kinases 1-5 (designated AK1-5) are a set of enzymes that regulate the phosphorylation state of intracellular adenine nucleotides, which are the principle high-energy phosphoryl-carrying molecules in living cells. AKs influence metabolic signals, which include gene expression, ion channel activity and protein kinase-mediated signaling, by catalyzing phosphoryl transfer between adenine nucleotides (AMP, ADP, ATP). Inherited mutations leading to AK deficiencies in erythrocytes have been implicated in hemolytic anemia. AK2 is found in the mitochondria of liver and heart tissues and is the only AK that localizes to the mitochondrial intermembrane space. In apoptotic cells, AK2 is the only AK that translocates into the cytosol concomitantly with cytochrome c, suggesting that only intermembrane proteins are released from mitochondria during the early stages of apoptosis.
Alternative Name:
Adenylate kinase 2, mitochondrial, AK 2, ATP-AMP transphosphorylase 2, ATP:AMP phosphotransferase, Adenylate monophosphate kinase, AK2, ADK2
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: AK2 polyclonal antibody detects endogenous levels of AK2 protein.
Immunogen:
Recombinant full length Human AK2.
MW: ~ 26 kDa
Swis Prot.: P54819
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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