AKAP3 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61005
Background:
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP). AKAP 3, also known as AKAP 110, FSP95, PRKA3 and SOB1, binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP 3 in normal tissues is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP 3, thereby increasing its recruitment of PKA. AKAP-3 also exhibits high expression in patients with epithelial ovarian cancer (EOC). It demonstrates tumor-restricted expression and appears to be associated with worse overall survival, which make AKAP 3 a potential target for antigen-specific immunotherapy in EOC.
Alternative Name:
A-kinase anchor protein 3, AKAP-3, A-kinase anchor protein 110 kDa, AKAP 110, Cancer/testis antigen 82, CT82, Fibrous sheath protein of 95 kDa, FSP95, Fibrousheathin I, Fibrousheathin-1, Protein kinase A-anchoring protein 3, PRKA3, Sperm oocyte-binding protein, AKAP3, AKAP110, SOB1
Application Dilution: WB: 1:500~1:1000
Specificity: AKAP3 polyclonal antibody detects endogenous levels of AKAP3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human AKAP3.
MW: ~ 95 kDa
Swis Prot.: O75969
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The type II cAMP-dependent protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins, designated A-kinase anchoring proteins (AKAP). AKAP 3, also known as AKAP 110, FSP95, PRKA3 and SOB1, binds both PKA and PDE4A and functions as a scaffolding protein in spermatozoa to regulate local cAMP concentrations and modulate sperm functions. Expression of AKAP 3 in normal tissues is restricted to the testis, where bicarbonate stimulates tyrosine phosphorylation of AKAP 3, thereby increasing its recruitment of PKA. AKAP-3 also exhibits high expression in patients with epithelial ovarian cancer (EOC). It demonstrates tumor-restricted expression and appears to be associated with worse overall survival, which make AKAP 3 a potential target for antigen-specific immunotherapy in EOC.
Alternative Name:
A-kinase anchor protein 3, AKAP-3, A-kinase anchor protein 110 kDa, AKAP 110, Cancer/testis antigen 82, CT82, Fibrous sheath protein of 95 kDa, FSP95, Fibrousheathin I, Fibrousheathin-1, Protein kinase A-anchoring protein 3, PRKA3, Sperm oocyte-binding protein, AKAP3, AKAP110, SOB1
Application Dilution: WB: 1:500~1:1000
Specificity: AKAP3 polyclonal antibody detects endogenous levels of AKAP3 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human AKAP3.
MW: ~ 95 kDa
Swis Prot.: O75969
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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