AKT1 (clone 3A3), anti-human, mouse, monkey
€429.00
In stock
SKU
252960
Catalog Nr.: 252960
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB
Size: 0.1 ml
Isotype: Mouse IgG1
Applications: E, WB
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Cancers, Cell Communication, Cell Growth and Death, Endocrine System, Immune System, Signal Transduction
Description:
AKT1 (RAC-alpha serine/threonine-protein kinase) is a key modulator of the AKT-mTOR signaling pathway. It controls the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. AKT1 signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT1 plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. AKT1 mediates the antiapoptotic effects of IGF-I. Defects in AKT1 are a cause of susceptibility to breast cancer (BC), a common malignancy originating from breast epithelial tissue.
Alternate Names: RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, RAC
Application Notes: E: 1:10000; WB: 1:500-1:2000
Accession No.: P31749
Antigen: Purified recombinant fragment of human AKT1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Cell Communication, Cell Growth and Death, Endocrine System, Immune System, Signal Transduction
Description:
AKT1 (RAC-alpha serine/threonine-protein kinase) is a key modulator of the AKT-mTOR signaling pathway. It controls the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. AKT1 signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT1 plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. AKT1 mediates the antiapoptotic effects of IGF-I. Defects in AKT1 are a cause of susceptibility to breast cancer (BC), a common malignancy originating from breast epithelial tissue.
Alternate Names: RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha, Protein kinase B, PKB, C-AKT, AKT1, RAC
Application Notes: E: 1:10000; WB: 1:500-1:2000
Accession No.: P31749
Antigen: Purified recombinant fragment of human AKT1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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