AKT1 (clone ), anti-human, mouse
€428.00
In stock
SKU
MB9025
Background:
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer.
Alternative Name:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC, PKBα,
Application Dilution: WB: 1:2000, IHC/ICC: 1:100-1:200, FC: 100-1:200
Specificity: This antibody detects endogenous levels of AKT1 and does not cross-react with related proteins.
Immunogen:
This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of AKT1.
MW: ~ 60 kDa
Swis Prot.: P31749
Purification & Purity:
Protein A affinity purified
Format:
Mouse IgG2b. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH) domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer.
Alternative Name:
RAC-alpha serine/threonine-protein kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, AKT1, PKB, RAC, PKBα,
Application Dilution: WB: 1:2000, IHC/ICC: 1:100-1:200, FC: 100-1:200
Specificity: This antibody detects endogenous levels of AKT1 and does not cross-react with related proteins.
Immunogen:
This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to a region of AKT1.
MW: ~ 60 kDa
Swis Prot.: P31749
Purification & Purity:
Protein A affinity purified
Format:
Mouse IgG2b. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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