AKTIP polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7983
Background:
Fused toes protein homolog (FTS), also known as AKT-interacting protein (AKTIP) and Ft1, is a 292 amino acid protein that localizes to the cytoplasm and the cell membrane. A member of the ubiquitin-conjugating enzyme family, FTS binds directly to AKT1 to regulate apoptosis in a cell population. AKT1 is a protein that plays a critical role in a number of cellular responses, such as cell growth, protein synthesis, and antiapoptotic signaling. The interaction of FTS and AKT1 enhances the phosphorylation and activation of AKT1, which, through an AKT1/GSK-3β/NFATc1 signaling cascade, results in the increased production of the proapoptotic hormone Fas ligand and thus an increase in apoptosis.
Alternative Name:
AKT interacting protein, AKT-interacting protein, AKTIP, AKTIP_HUMAN, FT 1, FT1, Fused toes homolog, Fused toes protein homolog,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: AKTIP polyclonal antibody detects endogenous levels of AKTIP protein.
Immunogen:
Recombinant full length Human AKTIP.
MW: ~ 58 kDa
Swis Prot.: Q9H8T0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Fused toes protein homolog (FTS), also known as AKT-interacting protein (AKTIP) and Ft1, is a 292 amino acid protein that localizes to the cytoplasm and the cell membrane. A member of the ubiquitin-conjugating enzyme family, FTS binds directly to AKT1 to regulate apoptosis in a cell population. AKT1 is a protein that plays a critical role in a number of cellular responses, such as cell growth, protein synthesis, and antiapoptotic signaling. The interaction of FTS and AKT1 enhances the phosphorylation and activation of AKT1, which, through an AKT1/GSK-3β/NFATc1 signaling cascade, results in the increased production of the proapoptotic hormone Fas ligand and thus an increase in apoptosis.
Alternative Name:
AKT interacting protein, AKT-interacting protein, AKTIP, AKTIP_HUMAN, FT 1, FT1, Fused toes homolog, Fused toes protein homolog,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: AKTIP polyclonal antibody detects endogenous levels of AKTIP protein.
Immunogen:
Recombinant full length Human AKTIP.
MW: ~ 58 kDa
Swis Prot.: Q9H8T0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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