ALK Antibody (Center) Blocking Peptide
€363.00
In stock
SKU
AC-BP7600c
Background:
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7600c was selected from the Center region of human ALK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7600c was selected from the Center region of human ALK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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