ALK Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP11211a
Background:
The 2;5 chromosomal translocation is frequently associatedwith anaplastic large cell lymphomas (ALCLs). The translocationcreates a fusion gene consisting of the ALK (anaplastic lymphomakinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK,derived from chromosome 2, is fused to the 5' portion of NPM fromchromosome 5. A recent study shows that the product of the NPM-ALKfusion gene is oncogenic. The deduced amino acid sequences revealthat ALK is a novel receptor protein-tyrosine kinase having aputative transmembrane domain and an extracellular domain. Thesesequences are absent in the product of the transforming NPM-ALKgene. ALK shows the greatest sequence similarity to LTK (leukocytetyrosine kinase). ALK plays an important role in the development ofthe brain and exerts its effects on specific neurons in the nervoussystem.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The 2;5 chromosomal translocation is frequently associatedwith anaplastic large cell lymphomas (ALCLs). The translocationcreates a fusion gene consisting of the ALK (anaplastic lymphomakinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK,derived from chromosome 2, is fused to the 5' portion of NPM fromchromosome 5. A recent study shows that the product of the NPM-ALKfusion gene is oncogenic. The deduced amino acid sequences revealthat ALK is a novel receptor protein-tyrosine kinase having aputative transmembrane domain and an extracellular domain. Thesesequences are absent in the product of the transforming NPM-ALKgene. ALK shows the greatest sequence similarity to LTK (leukocytetyrosine kinase). ALK plays an important role in the development ofthe brain and exerts its effects on specific neurons in the nervoussystem.
Other Names:
ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Gene Name: ALK {ECO:0000303|PubMed:9174053, ECO:0000312|HGNC:HGNC:427}
Gene ID: 238
Primary Accession: Q9UM73
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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