ALK Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP7600a
Background:
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Other Names: ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7600a was selected from the N-term region of human ALK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UM73
Gene ID: 238
Gene Name: ALK
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Morris, S.W., et al., Oncogene 14(18):2175-2188 (1997).Iwahara, T., et al., Oncogene 14(4):439-449 (1997).Morris, S.W., et al., Science 263(5151):1281-1284 (1994).Morris, S.W., et al., Oncogene 15, 2883-2883 (1997).
ALK, a member of the insulin receptor subfamily of Tyr protein kinases, is an orphan receptor. It appears to play an important role in the normal development and function of the nervous system. This Type I membrane protein is expressed in brain and CNS and in the small intestine and testis, but not in normal lymphoid cells. A form of non-Hodgkin's lymphoma is characterized by a chromosomal translocation t(2;5)(p23;q35) that involves NPM1 and ALK. The protein contains 1 LDL-receptor class A domain and 2 putative MAM domains.
Other Names: ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD246, ALK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7600a was selected from the N-term region of human ALK . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UM73
Gene ID: 238
Gene Name: ALK
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Morris, S.W., et al., Oncogene 14(18):2175-2188 (1997).Iwahara, T., et al., Oncogene 14(4):439-449 (1997).Morris, S.W., et al., Science 263(5151):1281-1284 (1994).Morris, S.W., et al., Oncogene 15, 2883-2883 (1997).
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