ALK (phospho Tyr1604) Polyclonal Antibody

Background:
anaplastic lymphoma receptor tyrosine kinase(ALK) Homo sapiens This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome

Alternative Names:
ALK, ALK tyrosine kinase receptor, Anaplastic lymphoma kinase, CD antigen CD246

Immunogen: The antiserum was produced against synthesized peptide derived from human ALK around the phosphorylation site of Tyr1604. AA range:1570-1619

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 176

GeneID: ALK

Storage: -20°C/1 year

NOTE: For Research Use Only