Alkaline Phosphatase (Placental)/PLAP [clone SP15], anti-human, mouse

Description: Alkaline phosphatases (ALP) are dimeric enzymes by glycosylphosphatidylinositol anchors to the cell membrane. There are at least four distinct but related isozymes: placenta ALP (PLAP), germ cell ALP (PLAP-like or GCAP), intestinal ALP (IAP) and non-specific tissue ALP (TNAP). These isozymes may serve to guide migratory cells, to transport specific molecules such as fat and immunoglobulins across membranes or to detoxify lipopolysaccharide and prevent bacterial invasion across the gut mucosal barrier. This antibody reacts with a membrane-bound isoenzyme of placental alkaline phosphatase (PLAP) occurring in the placents during the 3rd trimester of gestation. It is expressed in testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).Localization: membraneDilution: 50-200Positive Control: seminoma, placentaHIER: citrate pH6.0 or EDTA pH8.0Status: RUO