ALOX15 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8547
Background:
The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Alternative Name:
Arachidonate 15-lipoxygenase (EC:1.13.11.33), 15-LOX, 15-LOX-1, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type (EC:1.13.11.31), 12-LOX, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: ALOX15 polyclonal antibody detects endogenous levels of ALOX15 protein.
Immunogen:
Recombinant full length Human ALOX15.
MW: ~ 75kDa
Swis Prot.: P16050
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Alternative Name:
Arachidonate 15-lipoxygenase (EC:1.13.11.33), 15-LOX, 15-LOX-1, 12/15-lipoxygenase, Arachidonate 12-lipoxygenase, leukocyte-type (EC:1.13.11.31), 12-LOX, Arachidonate omega-6 lipoxygenase, ALOX15, LOG15
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: ALOX15 polyclonal antibody detects endogenous levels of ALOX15 protein.
Immunogen:
Recombinant full length Human ALOX15.
MW: ~ 75kDa
Swis Prot.: P16050
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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