ALOX5 (phospho-S271) polyclonal, anti-human
€428.00
In stock
SKU
BS74009
Background:
5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane.
Alternative Name:
5-LO, 5LPG, LOG5, 5-LOX,
Application Dilution: WB: 1:500 - 1:2000
Specificity: ALOX5 (phospho-S271) polyclonal antibody detects endogenous levels of ALOX5 protein only when phosphorylated at Ser271.
Immunogen:
A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5.
MW: ~ 78 kDa
Swis Prot.: P09917
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane.
Alternative Name:
5-LO, 5LPG, LOG5, 5-LOX,
Application Dilution: WB: 1:500 - 1:2000
Specificity: ALOX5 (phospho-S271) polyclonal antibody detects endogenous levels of ALOX5 protein only when phosphorylated at Ser271.
Immunogen:
A phospho specific peptide corresponding to residues surrounding S271 of human ALOX5.
MW: ~ 78 kDa
Swis Prot.: P09917
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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