Alpha-1 Antitrypsin polyclonal, anti-human, mouse, rat, rabbit, dog, pig, sheep, bovine
€378.00
In stock
SKU
250475
Catalog Nr.: 250475
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Enzymes, Peptidases
Pathway and Disease: Immune System; Folding, Sorting, and Degradation
Description:
AAT (Alpha-1-antitrypsin) is an inhibitor of serine proteases. Although AAT's primary target is elastase, the enzyme has also a moderate affinity for plasmin and thrombin. AAT inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. AAT deficiency is related to emphysema and liver disease.
Alternate Names: Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1, AAT, PI
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-500
Accession No.: P01009
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AAT.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Carpe N. et al. 2010. Am. J. Respir. Cell Mol. Biol.43(6):720-730 . PMID# 20118217.
Pathway and Disease: Immune System; Folding, Sorting, and Degradation
Description:
AAT (Alpha-1-antitrypsin) is an inhibitor of serine proteases. Although AAT's primary target is elastase, the enzyme has also a moderate affinity for plasmin and thrombin. AAT inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. AAT deficiency is related to emphysema and liver disease.
Alternate Names: Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, SERPINA1, AAT, PI
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-500
Accession No.: P01009
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AAT.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
Carpe N. et al. 2010. Am. J. Respir. Cell Mol. Biol.43(6):720-730 . PMID# 20118217.
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