Alpha-actinin-4 polyclonal, anti-human

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Cell Motility, Cell Communication, Immune System, Infectious Diseases

Description:
Alpha-actinin-4 is a cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Alpha-actinin-4 is involved in vesicular trafficking via its association with the CART complex. Defects in alpha-actinin-4 are the cause of focal segmental glomerulosclerosis type 1 (FSGS1), a renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema.

Alternate Names: Alpha-actinin-4, Non-muscle alpha-actinin 4, F-actin cross-linking protein, ACTN4

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: O43707

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human alpha-actinin-4.

Format: Each vial contains 0.1 mg serum in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.