Alpha-Conotoxin IMI Peptide
€194.00
In stock
SKU
350460
Protein Family: Hormones, Receptors and Channels
Pathway and Disease: Nervous and Sensory Systems, Signaling Molecules and Interactions
Alternate Names: Alpha-conotoxin ImI; alpha-CTx ImI
Accession No.: P50983
Description:
Alpha-conotoxin IMI is a 12-aa toxin isolated from the cone snail Conus imperialis venom. Alpha-conotoxin IMI is a potent blocker of the alpha/delta nicotinic acetylcholine channel receptors (nAChR) located on postsynaptic membranes. Alpha-conotoxin IMI inhibits in a voltage independent manner mammalian neuronal nAChRs (a3/b2 > a7 > a3/b4) and has no effect on nAChRs composed of a2/b2, a3/b2, a4/b2, a2/b4, a3/b4, or a4/b4 subunits. This toxin is highly active against the neuromuscular receptor in frog.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1347.58 g/mol
Sequence:
H-Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Cys2-Cys8, Cys3-Cys12) or H-GCCSDPRCAWRC-NH2 (Cys2-Cys8, Cys3-Cys12)
Composition:
C52H74N20O15S4
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
Pathway and Disease: Nervous and Sensory Systems, Signaling Molecules and Interactions
Alternate Names: Alpha-conotoxin ImI; alpha-CTx ImI
Accession No.: P50983
Description:
Alpha-conotoxin IMI is a 12-aa toxin isolated from the cone snail Conus imperialis venom. Alpha-conotoxin IMI is a potent blocker of the alpha/delta nicotinic acetylcholine channel receptors (nAChR) located on postsynaptic membranes. Alpha-conotoxin IMI inhibits in a voltage independent manner mammalian neuronal nAChRs (a3/b2 > a7 > a3/b4) and has no effect on nAChRs composed of a2/b2, a3/b2, a4/b2, a2/b4, a3/b4, or a4/b4 subunits. This toxin is highly active against the neuromuscular receptor in frog.
Format:
Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt.
MW: 1347.58 g/mol
Sequence:
H-Gly-Cys-Cys-Ser-Asp-Pro-Arg-Cys-Ala-Trp-Arg-Cys-NH2 (Cys2-Cys8, Cys3-Cys12) or H-GCCSDPRCAWRC-NH2 (Cys2-Cys8, Cys3-Cys12)
Composition:
C52H74N20O15S4
Purity:
> 95% by HPLC
Solubility:
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
Storage:
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
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