ALPK1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP7109a
Background:
Unlike most eukaryotic kinases, alpha kinases, such as ALPK1, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Epithelial cells maintain a polarized structure based on a selective sorting machinery for cargo traveling to the apical or the basolateral membrane domain at the trans-Golgi network exit. Alpha-kinase 1 (ALPK1)is a compnent of raft-carrying apical vesicles, originally identified in vesicles ferrying raft-associated sucrase-isomaltase (SI). It has been proposed that phosphorylation of myosin I by ALPK1 is essential to the apical trafficking of raft-associated SI.
Other Names:
Alpha-protein kinase 1, 2711-, Chromosome 4 kinase, Lymphocyte alpha-protein kinase, ALPK1, KIAA1527, LAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7109a was selected from the N-term region of human ALPK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ALPK1 {ECO:0000303|PubMed:30111836, ECO:0000312|HGNC:HGNC:20917}
Gene ID: 80216
Primary Accession: Q96QP1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Unlike most eukaryotic kinases, alpha kinases, such as ALPK1, recognize phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Epithelial cells maintain a polarized structure based on a selective sorting machinery for cargo traveling to the apical or the basolateral membrane domain at the trans-Golgi network exit. Alpha-kinase 1 (ALPK1)is a compnent of raft-carrying apical vesicles, originally identified in vesicles ferrying raft-associated sucrase-isomaltase (SI). It has been proposed that phosphorylation of myosin I by ALPK1 is essential to the apical trafficking of raft-associated SI.
Other Names:
Alpha-protein kinase 1, 2711-, Chromosome 4 kinase, Lymphocyte alpha-protein kinase, ALPK1, KIAA1527, LAK
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7109a was selected from the N-term region of human ALPK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: ALPK1 {ECO:0000303|PubMed:30111836, ECO:0000312|HGNC:HGNC:20917}
Gene ID: 80216
Primary Accession: Q96QP1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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