AMACR (C-terminus) (clone ), anti-rat

Background:
P504S, also known as AMACR (a-methylacyl-CoA racemase), 2-methylacyl-CoA racemase or RACE, is an enzyme belonging to the caiB/baiF CoA-transferase family. Localizing to the peroxisome and mitochondrion, P504S plays a role in the metabolism of branched-chain fatty acids and bile acid intermediates. More specifically, P504S catalyzes the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers which can then be degraded by peroxisomal b-oxidation. Mutations in the gene encoding P504S can lead to AMACR deficiency, a disease characterized by increased concentrations of pristanic acid that is associated with adult onset sensory motor neuropathy.

Alternative Name:
Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACR

Application Dilution: WB: 1:1000, ICC: 1:50~200

Specificity: This antibody detects endogenous levels of AMACR and does not cross-react with related proteins

Immunogen:
Synthetic peptide, corresponding to the C-terminus of Human AMACR.

MW: Predicted band size: 42KDa , Observed band size: 42KDa

Swis Prot.: Q9UHK6

Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Format:
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.