AMPK alpha-1 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Endocrine System, Signal Transduction

Description:
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha-1) is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. AMPK alpha-1 also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. AMPK alpha-1 acts as a metabolic stress-sensing protein kinase that switches off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia.

Alternate Names: AMPK alpha-1 chain, AMP-activated Protein Kinase alpha-1, 5'-AMP-activated protein kinase catalytic subunit alpha-1, PRKAA1, AMPK1

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: Q13131

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human protein C-AMPK alpha-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.