AMPK alpha-2 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Endocrine System, Signal Transduction

Description:
5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK alpha-2 Antibody) is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. AMPK alpha-2 regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. AMPK alpha-2 acts as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia.

Alternate Names: 5'-AMP-activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, PRKAA2, AMPK, AMPK2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P54646

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human AMPK alpha-2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.