AMPK gamma (PRKAG1) Antibody (Center) Blocking peptide
€293.00
In stock
SKU
AC-BP7048c
Background:
PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Other Names: 5'-AMP-activated protein kinase subunit gamma-1, AMPK gamma1, AMPK subunit gamma-1, AMPKg, PRKAG1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7048c was selected from the Center region of human PRKAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P54619
Other Accession: NP_997626
Gene ID: 5571
Gene Name: PRKAG1
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Minokoshi, Y., et al., Nature 428(6982):569-574 (2004).Hamilton, S.R., et al., FEBS Lett. 500(3):163-168 (2001).Zidovetzki, R., et al., AIDS Res. Hum. Retroviruses 14(10):825-833 (1998).Reinton, N., et al., Genomics 49(2):290-297 (1998).Stapleton, D., et al., FEBS Lett. 409(3):452-456 (1997).
PRKAG1 is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK.
Other Names: 5'-AMP-activated protein kinase subunit gamma-1, AMPK gamma1, AMPK subunit gamma-1, AMPKg, PRKAG1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7048c was selected from the Center region of human PRKAG1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: P54619
Other Accession: NP_997626
Gene ID: 5571
Gene Name: PRKAG1
Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Bio References:
Minokoshi, Y., et al., Nature 428(6982):569-574 (2004).Hamilton, S.R., et al., FEBS Lett. 500(3):163-168 (2001).Zidovetzki, R., et al., AIDS Res. Hum. Retroviruses 14(10):825-833 (1998).Reinton, N., et al., Genomics 49(2):290-297 (1998).Stapleton, D., et al., FEBS Lett. 409(3):452-456 (1997).
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