Anacardic Acid

A multi-use enzyme activator and inhibitor. Itis a pentadecane aliphatic chain containing hydroxylcarboxylic acid. The acid is an effective inhibitor of the activities of p300, p300/CBP associated factor histone acetyltransferase, prostaglandin synthase (PTGS2 or Cox-2), tyrosinase, urease-α and -β, lipoxygenase (LO), and xanthine oxidase. Additionally, it has been shown to potently inhibit HAT-dependent transcription and SUMOylation, as well as decrease expression of NF-κB regulated gene products at high concentrations. Research suggests that anacardic acid is a potent activator of ARK-1 (Aurora kinase A) mediated phosphorylation of histone H3 while leaving ARK-2 unaffected in vitro. Anacardic acid has demonstrated bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA).

Synonym: 2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA
Source: Synthetic.
Storage and Stability: Stock solutions are stable for up to 3 months when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C.

Appearance: Powder
Boiling Point: 474.82 ¡ãC at 760 mmHg
Density: 1.00 g/cm3
Melting Point: 33.9-37.2 ¡ãC

Molecular Weight: 348.52
Molecular Formula: C22H36O3
Purity: >95%
Storage: 2-8°C
Solubility: Soluble in ether, petroleum ether, DMSO (>20 mg/mL), DMF (~10 mg/mL), ethanol (~10 mg/mL), a1:1 solution of ethanol:PBS(pH7.2) (~0.5 mg/ml), methanol, dichloromethane, and ethyl acetate.
Appearance Form: Powder
Appearance Color: White to beige
Melting Point: 33.9 - 37.2°C
Brand Name: bioPLUS™