ANAPC10 Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP9135a
Background:
APC is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds 1/Cut 2 and cyclin B. It was found that APC 10/Doc 1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in mid body in telophase and cytokinesis. These results strongly support the notion that human APC 10/Doc 1 may be one of the APC core subunits rather than the transiently associated regulatory factor.
Other Names: Anaphase-promoting complex subunit 10, APC10, Cyclosome subunit 10, ANAPC10, APC10
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9135a was selected from the N-term region of human ANAPC10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UM13
Gene ID: 10393
Gene Name: ANAPC10
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Wendt K.S., et.al., Nat. Struct. Biol. 8:784-788(2001).
APC is a ubiquitin ligase which specifically targets mitotic regulatory factors such as Pds 1/Cut 2 and cyclin B. It was found that APC 10/Doc 1 is localized in centrosomes and mitotic spindles throughout mitosis, while it is also localized in kinetochores from prophase to anaphase and in mid body in telophase and cytokinesis. These results strongly support the notion that human APC 10/Doc 1 may be one of the APC core subunits rather than the transiently associated regulatory factor.
Other Names: Anaphase-promoting complex subunit 10, APC10, Cyclosome subunit 10, ANAPC10, APC10
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9135a was selected from the N-term region of human ANAPC10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UM13
Gene ID: 10393
Gene Name: ANAPC10
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Wendt K.S., et.al., Nat. Struct. Biol. 8:784-788(2001).
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