ANAPC7 Antibody (Center) Blocking Peptide
€293.00
In stock
SKU
AC-BP9218c
Background:
APC7 is one of the subunits of the Anaphase Promoting Complex. APC7 (anaphase-promoting complex subunit 7) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 63 kD. The APC7 protein is located in the nucleus during interphase and the centrosome during metaphase/anaphase. This protein probably recruits Cdh1 into the APC complex. The APC7 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC6 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Other Names: Anaphase-promoting complex subunit 7, APC7, Cyclosome subunit 7, ANAPC7, APC7
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9218c was selected from the Center region of human ANAPC7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UJX3
Gene ID: 51434
Gene Name: ANAPC7
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Nilsson J. et al., Nat Cell Biol 10:1411-20 (2008).
APC7 is one of the subunits of the Anaphase Promoting Complex. APC7 (anaphase-promoting complex subunit 7) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 63 kD. The APC7 protein is located in the nucleus during interphase and the centrosome during metaphase/anaphase. This protein probably recruits Cdh1 into the APC complex. The APC7 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC6 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1.
Other Names: Anaphase-promoting complex subunit 7, APC7, Cyclosome subunit 7, ANAPC7, APC7
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP9218c was selected from the Center region of human ANAPC7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9UJX3
Gene ID: 51434
Gene Name: ANAPC7
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Nilsson J. et al., Nat Cell Biol 10:1411-20 (2008).
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