ANG polyclonal, anti-human, mouse
€305.00
In stock
SKU
BS60510
Background:
Angiogenesis is defined as the process of neovascularization and formation of new blood vessels from the established micro-circulation. Angiogenin (ANG or ANG I) is a non-glycosylated polypeptide, 123 amino acids in length, whose function is central to this process. ANG I shows a high degree of homology with known ribonucleases such as pancreatic ribonuclease A, and the capacity of ANG I to induce blood vessel growth is critically dependent on its ribonucleolytic activity. ANG I is thought to be involved in the development of solid tumors, and ANG I antagonists are capable of inhibiting tumor growth. By a poorly understood mechanism, ANG I is endocytosed by subconfluent endothelial cells and translocated to the nucleus where it accumulates in the nucleolus. The ANG I receptor has not yet been identified.
Alternative Name:
Angiogenin, Ribonuclease 5, RNase 5, ANG, RNASE5
Application Dilution: IHC:1:50~1:200
Specificity: ANG polyclonal antibody detects endogenous levels of ANG protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ANG
MW: ~ 17 kDa
Swis Prot.: P03950
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Angiogenesis is defined as the process of neovascularization and formation of new blood vessels from the established micro-circulation. Angiogenin (ANG or ANG I) is a non-glycosylated polypeptide, 123 amino acids in length, whose function is central to this process. ANG I shows a high degree of homology with known ribonucleases such as pancreatic ribonuclease A, and the capacity of ANG I to induce blood vessel growth is critically dependent on its ribonucleolytic activity. ANG I is thought to be involved in the development of solid tumors, and ANG I antagonists are capable of inhibiting tumor growth. By a poorly understood mechanism, ANG I is endocytosed by subconfluent endothelial cells and translocated to the nucleus where it accumulates in the nucleolus. The ANG I receptor has not yet been identified.
Alternative Name:
Angiogenin, Ribonuclease 5, RNase 5, ANG, RNASE5
Application Dilution: IHC:1:50~1:200
Specificity: ANG polyclonal antibody detects endogenous levels of ANG protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ANG
MW: ~ 17 kDa
Swis Prot.: P03950
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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