ANG2 polyclonal, anti-human, mouse, rat
€402.00
In stock
SKU
252056
Catalog Nr.: 252056
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Protein Family: Cytokines
Pathway and Disease: Signaling Molecules and Interaction; Cell Growth and Death
Description:
Angiopoietin-2 (ANG2) induces tyrosine phosphorylation of TIE2. ANG2 binds to the TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. ANG2 function is context-dependent: In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, ANG2 facilitates endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal
Alternate Names: ANGPT2, Angiopoietin-2, ANG-2, ANG2
Application Notes: E: 1:5,000-1:20,000; WB: 1:100-1:500; IHC: 1:50-1:200
Accession No.: O15123
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ANG2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction; Cell Growth and Death
Description:
Angiopoietin-2 (ANG2) induces tyrosine phosphorylation of TIE2. ANG2 binds to the TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. ANG2 function is context-dependent: In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, ANG2 facilitates endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal
Alternate Names: ANGPT2, Angiopoietin-2, ANG-2, ANG2
Application Notes: E: 1:5,000-1:20,000; WB: 1:100-1:500; IHC: 1:50-1:200
Accession No.: O15123
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ANG2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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