ANGPT2 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60367
Background:
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2.
Alternative Name:
Angiopoietin-2, ANG-2, Angiopoietin 2, ANG 2, Angiopoietin2, ANG2, ANGPT2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ANGPT2 polyclonal antibody detects endogenous levels of ANGPT2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ANGPT2.
MW: ~ 60 kDa
Swis Prot.: O15123
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Tie-1 and Tie-2 (also designated Tek) are novel cell surface receptor tyrosine kinases. The extracellular domain of Tie-1 has an unusual multidomain structure consisting of a cluster of three epidermal growth factor homology motifs localized between two immunoglobulin-like loops, which are followed by three fibronectin type III repeats next to the transmembrane region. Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2. Preliminary biochemical analyses of Ang-1 reveal a potential fibrinogen-like domain at the carboxy terminus and coiled-coil regions in the amino terminus. Ang-1 is an angiogenic factor that is thought to be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), has been identified as a naturally occurring antagonist of Ang-1 activation of Tie-2.
Alternative Name:
Angiopoietin-2, ANG-2, Angiopoietin 2, ANG 2, Angiopoietin2, ANG2, ANGPT2
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: ANGPT2 polyclonal antibody detects endogenous levels of ANGPT2 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human ANGPT2.
MW: ~ 60 kDa
Swis Prot.: O15123
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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