ANGPT2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6063
Background:
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Alternative Name:
Angiopoietin-2, ANG-2, Angiopoietin 2, ANG 2, Angiopoietin2, ANG2, ANGPT2
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:200
Specificity: ANGPT2 polyclonal antibody detects endogenous levels of ANGPT2 protein.
Immunogen:
Recombinant full length Human ANGPT2.
MW: ~ 57 kDa
Swis Prot.: O15123
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Alternative Name:
Angiopoietin-2, ANG-2, Angiopoietin 2, ANG 2, Angiopoietin2, ANG2, ANGPT2
Application Dilution: WB: 1:500 - 1:2000, IF: 1:50 - 1:200
Specificity: ANGPT2 polyclonal antibody detects endogenous levels of ANGPT2 protein.
Immunogen:
Recombinant full length Human ANGPT2.
MW: ~ 57 kDa
Swis Prot.: O15123
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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