ANP32A polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7847
Background:
Protein phosphatase 2A PP2A is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. ANP32A, also known as Inhibitor 1 of PP2A (I1PP2A), and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. ANP32A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The ANP32A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms’ tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
Alternative Name:
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, AN32A_HUMAN, ANP32A, C15orf1, Cerebellar leucine rich acidic nuclear protein, Hepatopoietin Cn, HPPCn, I1PP2A, Inhibitor 1 of protein phosphatase 2A, inhibitor-1 of protein phosphatase-2A, Lanp, Leucine Rich Acidic Nuclear Protein, Leucine-rich acidic nuclear protein, MAPM, Mapmodulin, MGC119787, MGC150373, PHAPI, Potent heat stable protein phosphatase 2A inhibitor I1PP2A, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, PP32, Putative HLA DR associated protein I, Putative HLA-DR-associated protein I, Putative Human HLA Class II Associated Protein, Putative human HLA class II associated protein I, Putative human HLA class II-associated protein,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: ANP32A polyclonal antibody detects endogenous levels of ANP32A protein.
Immunogen:
Recombinant full length Human ANP32A.
MW: ~ 32 kDa
Swis Prot.: P39687
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Protein phosphatase 2A PP2A is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. ANP32A, also known as Inhibitor 1 of PP2A (I1PP2A), and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. ANP32A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The ANP32A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms’ tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
Alternative Name:
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein 32 family member A, Acidic nuclear phosphoprotein pp32, AN32A_HUMAN, ANP32A, C15orf1, Cerebellar leucine rich acidic nuclear protein, Hepatopoietin Cn, HPPCn, I1PP2A, Inhibitor 1 of protein phosphatase 2A, inhibitor-1 of protein phosphatase-2A, Lanp, Leucine Rich Acidic Nuclear Protein, Leucine-rich acidic nuclear protein, MAPM, Mapmodulin, MGC119787, MGC150373, PHAPI, Potent heat stable protein phosphatase 2A inhibitor I1PP2A, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, PP32, Putative HLA DR associated protein I, Putative HLA-DR-associated protein I, Putative Human HLA Class II Associated Protein, Putative human HLA class II associated protein I, Putative human HLA class II-associated protein,
Application Dilution: WB: 1:500~1:2000, IHC/IF: 1:50~1:200
Specificity: ANP32A polyclonal antibody detects endogenous levels of ANP32A protein.
Immunogen:
Recombinant full length Human ANP32A.
MW: ~ 32 kDa
Swis Prot.: P39687
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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