ANTXR1 Antibody (Y382) Blocking Peptide
€293.00
In stock
SKU
AC-BP7746a
Background:
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Other Names: Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7746a was selected from the Y382 region of human ANTXR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9H6X2
Gene ID: 84168
Gene Name: ANTXR1
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Werner,E., J. Biol. Chem. 281 (32), 23227-23236 (2006)Wei,W., Cell 124 (6), 1141-1154 (2006)Rainey,G.J., Proc. Natl. Acad. Sci. U.S.A. 102 (37), 13278-13283 (2005)
ANTXR1 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes.
Other Names: Anthrax toxin receptor 1, Tumor endothelial marker 8, ANTXR1, ATR, TEM8
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP7746a was selected from the Y382 region of human ANTXR1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Type: Synthetic peptide
Primary Accession: Q9H6X2
Gene ID: 84168
Gene Name: ANTXR1
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Werner,E., J. Biol. Chem. 281 (32), 23227-23236 (2006)Wei,W., Cell 124 (6), 1141-1154 (2006)Rainey,G.J., Proc. Natl. Acad. Sci. U.S.A. 102 (37), 13278-13283 (2005)
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