AP-TNAP Antibody (N-term) Blocking Peptide
€293.00
In stock
SKU
AC-BP5010a
Background:
AP-TNAP is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Other Names: Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme, ALPL
Type: Synthetic peptide
Primary Accession: P05186
Gene ID: 249
Gene Name: ALPL
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Ermakov, S., et al. Bone 46(5):1244-1250(2010)Kannampuzha, J.V., et al. J. Rheumatol. 36(12):2758-2765(2009)Born, A.K., et al. Eur Cell Mater 18, 49-60 (2009)
AP-TNAP is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.
Other Names: Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, Alkaline phosphatase liver/bone/kidney isozyme, ALPL
Type: Synthetic peptide
Primary Accession: P05186
Gene ID: 249
Gene Name: ALPL
Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Bio References:
Ermakov, S., et al. Bone 46(5):1244-1250(2010)Kannampuzha, J.V., et al. J. Rheumatol. 36(12):2758-2765(2009)Born, A.K., et al. Eur Cell Mater 18, 49-60 (2009)
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