Apaf-1 (C-term) polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Peptidases

Pathway and Disease: Cancers, Cell Growth and Death, Cofactor and Vitamin Metabolism

Description:
Apoptosis protease activating factor-1 (Apaf-1) mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3) by forming oligomer upon binding with cytochrome c and dATP. Oligomeric Apaf-1 binds to pro-caspase 9 through their N-terminal CARD domains releasing mature caspase-9.

Alternate Names: Apoptotic protease-activating factor 1, Apaf-1, APAF1

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: O14727

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Apaf-1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.