APC polyclonal, anti-human, mouse, rat, xenopus

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signal Transduction, Cell Motility, Cancers

Description:
The adenomatous polyposis coli protein (APC) is a tumor suppressor that promotes rapid degradation of catenin-beta 1 (CTNNB1) and participates in Wnt signaling. The GSK3-beta protein kinase regulates its activity by phosphorylation. APC binds to PDZ domains of DLG1 and 3, to catenins, axin and MAPRE protein family including the EB members.

Alternate Names: Adenomatous polyposis coli protein, protein APC, DP2.5

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500

Accession No.: P25054, NP_000029

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human APC.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 15% glycerol with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.