APC polyclonal, anti-mouse

Protein Family: Cytoskeleton Proteins

Pathway and Disease: Signal Transduction, Cell Motility, Cancers

Description:
The adenomatous polyposis coli protein (APC) is a tumor suppressor that promotes rapid degradation of catenin-beta 1 (CTNNB1) and participates in Wnt signaling. The GSK3-beta protein kinase regulates its activity by phosphorylation. APC binds to PDZ domains of DLG1 and 3, to catenins, axin and MAPRE protein family including the EB members. This antibody recognizes an epitope in the C-terminal half of the mouse APC in ELISA, Western blot and immunofluorescent staining.

Alternate Names: Adenomatous polyposis coli protein, protein APC, DP2.5, mAPC, Apc

Application Notes: E: 5 mg/ml; WB: 1:2,000; IF: 1:200

Accession No.: Q61315, NP_031488

Antigen: Recombinant mouse APC[2170-2394] protein

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.