APC Polyclonal Antibody

Background:
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Research Area: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells

Synonyms:
APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46

Immunogen: Recombinant fusion protein of human APC (NP_000029.2).

Swissprot: P25054
Gene ID: 324

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "IHC 1:50-1:200 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.