APC1 (phospho-S688) polyclonal, anti-human
€328.00
In stock
SKU
BS4375
Background:
APC1 is 1 of at least 11 subunits of the anaphase promoting complex (APC), which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
Alternative Name:
Anaphase-promoting complex subunit 1, APC1, Cyclosome subunit 1, Mitotic checkpoint regulator, Testis-specific gene 24 protein, ANAPC1, TSG24
Application Dilution: WB: 1:500~1:1000
Specificity: p-APC1 (S688) pAb detects endogenous levels of APC1 protein only when phosphorylated at Ser688.
Immunogen:
Synthetic phosphopeptide derived from human APC1 around the phosphorylation site of Serine 688
MW: ~ 216 kDa
Swis Prot.: Q9H1A4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
APC1 is 1 of at least 11 subunits of the anaphase promoting complex (APC), which functions at the metaphase to anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.
Alternative Name:
Anaphase-promoting complex subunit 1, APC1, Cyclosome subunit 1, Mitotic checkpoint regulator, Testis-specific gene 24 protein, ANAPC1, TSG24
Application Dilution: WB: 1:500~1:1000
Specificity: p-APC1 (S688) pAb detects endogenous levels of APC1 protein only when phosphorylated at Ser688.
Immunogen:
Synthetic phosphopeptide derived from human APC1 around the phosphorylation site of Serine 688
MW: ~ 216 kDa
Swis Prot.: Q9H1A4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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