APE1 polyclonal, anti-human

Protein Family: Enzymes

Pathway and Disease: Replication and Repair

Description:
DNA-(apurinic or apyrimidinic site) lyase (APE1) is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APE1 are DNA repair and redox regulation of transcriptional factors. APE1 functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. APE initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.

Alternate Names: DNA-(apurinic or apyrimidinic site) lyase, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1, APE, APE1, APEX, APX, HAP1, REF1, APEX1

Application Notes: E: 1:10,000-1:50,000; WB: 1:100-1:1,000

Accession No.: P27695

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human APE1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.